abstract：:In this issue of Blood, Willems et al describe the dependence of acute myeloid leukemia (AML) cells on glutamine for maintaining protein synthesis downstream of mammalian target of rapamycin (mTOR) and show that the enzyme asparaginase can be used to target this dependence. Using various AML cell lines, primary sample...

journal_title：Blood

authors： Samudio I,Konopleva M

更新日期：2013-11-14 00:00:00

abstract：:Platelet endothelial cell adhesion molecule 1 (PECAM-1) is involved in leukocyte migration and angiogenesis, which are key components of venous thrombus resolution. This study investigated the effect of PECAM-1 deficiency on thrombus resolution in FVB/n mice and the extent to which levels of soluble PECAM-1 (sPECAM-1)...

journal_title：Blood

authors： Kellermair J,Redwan B,Alias S,Jabkowski J,Panzenboeck A,Kellermair L,Winter MP,Weltermann A,Lang IM

更新日期：2013-11-07 00:00:00

abstract：:The report of the so-called Berlin patient cured of HIV with hematopoietic stem cell transplantation and a few other studies raised tremendous hope, excitement, and curiosity in the field. The National Heart, Lung and Blood Institute of the National Institutes of Health convened a Working Group to address emerging hea...

journal_title：Blood

authors： Zou S,Glynn S,Kuritzkes D,Shah M,Cook N,Berliner N,NHLBI AIDS Blood Session Working Group.

更新日期：2013-10-31 00:00:00

abstract：:Human cord blood (CB) offers an attractive source of cells for clinical transplants because of its rich content of cells with sustained repopulating ability in spite of an apparent deficiency of cells with rapid reconstituting ability. Nevertheless, the clonal dynamics of nonlimiting CB transplants remain poorly under...

journal_title：Blood

authors： Cheung AM,Nguyen LV,Carles A,Beer P,Miller PH,Knapp DJ,Dhillon K,Hirst M,Eaves CJ

更新日期：2013-10-31 00:00:00

abstract：:Blood platelets are anuclear cell fragments that are essential for blood clotting. Platelets are produced by bone marrow megakaryocytes (MKs), which extend protrusions, or so-called proplatelets, into bone marrow sinusoids. Proplatelet formation requires a profound reorganization of the MK actin and tubulin cytoskelet...

journal_title：Blood

authors： Pleines I,Dütting S,Cherpokova D,Eckly A,Meyer I,Morowski M,Krohne G,Schulze H,Gachet C,Debili N,Brakebusch C,Nieswandt B

更新日期：2013-10-31 00:00:00

abstract：:In thrombophilic families, protein S deficiency is clearly associated with venous thrombosis. We aimed to determine whether the same holds true in a population-based case-control study (n = 5317). Subjects were regarded protein S deficient when protein S levels were < 2.5th percentile of the controls. Free and total p...

journal_title：Blood

authors： Pintao MC,Ribeiro DD,Bezemer ID,Garcia AA,de Visser MC,Doggen CJ,Lijfering WM,Reitsma PH,Rosendaal FR

更新日期：2013-10-31 00:00:00

abstract：:Epratuzumab, a humanized anti-CD22 antibody, is currently in clinical trials of B-cell lymphomas and autoimmune diseases, demonstrating therapeutic activity in non-Hodgkin lymphoma (NHL) and systemic lupus erythematosus (SLE). Thus, epratuzumab offers a promising option for CD22-targeted immunotherapy, yet its mechani...

journal_title：Blood

authors： Rossi EA,Goldenberg DM,Michel R,Rossi DL,Wallace DJ,Chang CH

更新日期：2013-10-24 00:00:00

abstract：:Hematopoietic stem cell (HSC) transplantation is a lifesaving therapy for malignant and nonmalignant hematologic diseases and metabolic disorders. Although successful, hematopoietic transplantation can be hindered by inadequate stem cell number or poor engrafting efficiency. To overcome these deficits, we and others h...

journal_title：Blood

authors： Hoggatt J,Mohammad KS,Singh P,Pelus LM

更新日期：2013-10-24 00:00:00

abstract：:As tyrosine kinase inhibitors (TKIs) fail to induce long-term response in blast crisis chronic myelogenous leukemia (CML-BC) and Philadelphia chromosome-positive (Ph(+)) acute lymphoblastic leukemia (ALL), novel therapies targeting leukemia-dysregulated pathways are necessary. Exportin-1 (XPO1), also known as chromoso...

journal_title：Blood

authors： Walker CJ,Oaks JJ,Santhanam R,Neviani P,Harb JG,Ferenchak G,Ellis JJ,Landesman Y,Eisfeld AK,Gabrail NY,Smith CL,Caligiuri MA,Hokland P,Roy DC,Reid A,Milojkovic D,Goldman JM,Apperley J,Garzon R,Marcucci G,Shacham S

更新日期：2013-10-24 00:00:00

abstract：:In this issue of Blood, Baychelier et al identify a ligand for a major natural killer (NK) cell receptor that mediates natural cytotoxicity toward tumor cells, thus ending a search that lasted well over a decade. ...

journal_title：Blood

authors： Rajagopalan S,Long EO

更新日期：2013-10-24 00:00:00

abstract：:The Ikaros gene (Ikzf1) encodes a family of zinc-finger transcription factors implicated in hematopoietic cell differentiation. Here we show that Ikaros suppresses the development of basophils, which are proinflammatory cells of the myeloid lineage. In the absence of extrinsic basophil-inducing signals, Ikaros(-/-) (I...

journal_title：Blood

authors： Rao KN,Smuda C,Gregory GD,Min B,Brown MA

更新日期：2013-10-10 00:00:00

abstract：:The transcription factor CCAAT enhancer binding protein α (C/EBPα) is a master regulator in granulopoiesis and is frequently disrupted in acute myeloid leukemia (AML). We have previously shown that C/EBPα exerts its effects by regulating microRNAs (miRs) such as miR-223 and miR-34a. Here, we confirm miR-30c as a novel...

journal_title：Blood

authors： Katzerke C,Madan V,Gerloff D,Bräuer-Hartmann D,Hartmann JU,Wurm AA,Müller-Tidow C,Schnittger S,Tenen DG,Niederwieser D,Behre G

更新日期：2013-10-03 00:00:00

abstract：:Classical 5q- syndrome is an acquired macrocytic anemia of the elderly. Similar to Diamond Blackfan anemia (DBA), an inherited red cell aplasia, the bone marrow is characterized by a paucity of erythroid precursors. RPS14 deletions in combination with other deletions in the region have been implicated as causative of ...

journal_title：Blood

authors： Vlachos A,Farrar JE,Atsidaftos E,Muir E,Narla A,Markello TC,Singh SA,Landowski M,Gazda HT,Blanc L,Liu JM,Ellis SR,Arceci RJ,Ebert BL,Bodine DM,Lipton JM

更新日期：2013-10-03 00:00:00

abstract：:Caloric restriction (CR) is proposed to decrease tumorigenesis through a variety of mechanisms including effects on glycolysis. However, the understanding of how CR affects the response to cancer therapy is still rudimentary. Here, using the Eµ-Myc transgenic mouse model of B-cell lymphoma, we report that by reducing ...

journal_title：Blood

authors： Meynet O,Zunino B,Happo L,Pradelli LA,Chiche J,Jacquin MA,Mondragón L,Tanti JF,Taillan B,Garnier G,Reverso-Meinietti J,Mounier N,Michiels JF,Michalak EM,Carles M,Scott CL,Ricci JE

更新日期：2013-10-03 00:00:00

abstract：:The cytokine interleukin (IL)-7 exerts essential roles in lymph node (LN) organogenesis and lymphocyte development and homeostasis. Recent studies have identified lymphatic endothelial cells (LECs) as a major source of IL-7 in LNs. Here, we report that LECs not only produce IL-7, but also express the IL-7 receptor cha...

journal_title：Blood

authors： Iolyeva M,Aebischer D,Proulx ST,Willrodt AH,Ecoiffier T,Häner S,Bouchaud G,Krieg C,Onder L,Ludewig B,Santambrogio L,Boyman O,Chen L,Finke D,Halin C

更新日期：2013-09-26 00:00:00

abstract：:The principal aim of our study was to investigate whether patients transplanted more than 20 years ago for β-thalassemia major had a different health-related quality of life (HRQoL) compared with the general population. The Medical Outcomes Study 36-Item Short-Form Health Survey (SF-36) and the Functional Assessment o...

journal_title：Blood

authors： La Nasa G,Caocci G,Efficace F,Dessì C,Vacca A,Piras E,Sanna M,Marcias M,Littera R,Carcassi C,Lucarelli G

更新日期：2013-09-26 00:00:00

abstract：:Anaplastic large-cell lymphomas (ALCLs) encompass at least 2 systemic diseases distinguished by the presence or absence of anaplastic lymphoma kinase (ALK) expression. We performed genome-wide microRNA (miRNA) profiling on 33 ALK-positive (ALK[+]) ALCLs, 25 ALK-negative (ALK[-]) ALCLs, 9 angioimmunoblastic T-cell lymp...

journal_title：Blood

authors： Liu C,Iqbal J,Teruya-Feldstein J,Shen Y,Dabrowska MJ,Dybkaer K,Lim MS,Piva R,Barreca A,Pellegrino E,Spaccarotella E,Lachel CM,Kucuk C,Jiang CS,Hu X,Bhagavathi S,Greiner TC,Weisenburger DD,Aoun P,Perkins SL,McKeith

更新日期：2013-09-19 00:00:00

abstract：:Induced pluripotent stem cells (iPSCs) hold great promise for modeling human hematopoietic diseases. However, intrinsic variability in the capacities of different iPSC lines for hematopoietic development complicates comparative studies and is currently unexplained. We created and analyzed 3 separate iPSC clones from f...

journal_title：Blood

authors： Mills JA,Wang K,Paluru P,Ying L,Lu L,Galvão AM,Xu D,Yao Y,Sullivan SK,Sullivan LM,Mac H,Omari A,Jean JC,Shen S,Gower A,Spira A,Mostoslavsky G,Kotton DN,French DL,Weiss MJ,Gadue P

更新日期：2013-09-19 00:00:00

abstract：:Understanding the molecular pathogenesis of lymphoma has led to paradigm-changing treatment opportunities. One example involves tailoring specific agents based on the cell of origin in aggressive lymphomas. Germinal center (GC)-derived diffuse large B-cell lymphoma (DLBCL) is known to be driven by an addiction to Bcl6...

journal_title：Blood

authors： Amengual JE,Clark-Garvey S,Kalac M,Scotto L,Marchi E,Neylon E,Johannet P,Wei Y,Zain J,O'Connor OA

更新日期：2013-09-19 00:00:00

abstract：:Posttranslational protein modifications (PTMs) are necessary for cells to function properly. The role of PTMs in regulating immune responses, specifically those mediated by dendritic cells (DCs), which are critical for both innate and adaptive immunity, is not well understood. Utilizing multiple but complementary appr...

journal_title：Blood

authors： Mathewson N,Toubai T,Kapeles S,Sun Y,Oravecz-Wilson K,Tamaki H,Wang Y,Hou G,Sun Y,Reddy P

更新日期：2013-09-19 00:00:00

abstract：:In this issue of Blood, Jodele and colleagues report that defective complement regulation contributes to the development of thrombotic microangiopathy (TMA) after hematopoietic stem cell transplantation (HSCT) with important implications for diagnosis and management of this severe clinical complication. ...

journal_title：Blood

authors： Ricklin D,Cines DB

更新日期：2013-09-19 00:00:00

abstract：:Cancer patients are at increased risk of deep vein thrombosis and pulmonary embolism. The incidence among different groups of cancer patients varies considerably depending on clinical factors, the most important being tumor entity and stage. Biomarkers have been specifically investigated for their capacity of predicti...

journal_title：Blood

authors： Pabinger I,Thaler J,Ay C

更新日期：2013-09-19 00:00:00

abstract：:The SRC family kinases (SFKs) and the receptor tyrosine kinase c-Kit are activated in human acute myeloid leukemia (AML) cells. We show here that the SFKs LYN, HCK, or FGR are overexpressed and activated in AML progenitor cells. Treatment with the SFK and c-KIT inhibitor dasatinib selectively inhibits human AML stem/p...

journal_title：Blood

authors： Dos Santos C,McDonald T,Ho YW,Liu H,Lin A,Forman SJ,Kuo YH,Bhatia R

更新日期：2013-09-12 00:00:00

abstract：:Neutralizing antibodies (inhibitors) toward factor VIII form a severe complication in nonsevere hemophilia A, profoundly aggravating the bleeding pattern. Identification of high-risk patients is hampered by lack of data that take exposure days to therapeutic factor VIII concentrates into account. In the INSIGHT study,...

journal_title：Blood

authors： Eckhardt CL,van Velzen AS,Peters M,Astermark J,Brons PP,Castaman G,Cnossen MH,Dors N,Escuriola-Ettingshausen C,Hamulyak K,Hart DP,Hay CR,Haya S,van Heerde WL,Hermans C,Holmström M,Jimenez-Yuste V,Keenan RD,Klamroth R

更新日期：2013-09-12 00:00:00

abstract：:Intravital microscopy of the calvarium is the only noninvasive method for high-resolution imaging of the bone marrow (BM) and hematopoietic stem cell (HSC) niches. However, it is unclear if the calvarium is representative of all BM compartments. Using the combination of whole body optical imaging, intravital microscop...

journal_title：Blood

authors： Lassailly F,Foster K,Lopez-Onieva L,Currie E,Bonnet D

更新日期：2013-09-05 00:00:00

abstract：:The t(8;21) and inv(16)/t(16;16) rearrangements affecting the core-binding factors RUNX1 and CBFB, respectively, are found in 15% to 20% of adult de novo acute myeloid leukemia (AML) cases and are associated with a favorable prognosis. Since the expression of the fusion genes CBFB/MYH11 or RUNX1/RUNX1T1 alone is not s...

journal_title：Blood

authors： Opatz S,Polzer H,Herold T,Konstandin NP,Ksienzyk B,Zellmeier E,Vosberg S,Graf A,Krebs S,Blum H,Hopfner KP,Kakadia PM,Schneider S,Dufour A,Braess J,Sauerland MC,Berdel WE,Büchner T,Woermann BJ,Hiddemann W,Spiekerma

更新日期：2013-09-05 00:00:00

abstract：:Homologous recombination repair (HRR) protects cells from the lethal effect of spontaneous and therapy-induced DNA double-stand breaks. HRR usually depends on BRCA1/2-RAD51, and RAD52-RAD51 serves as back-up. To target HRR in tumor cells, a phenomenon called "synthetic lethality" was applied, which relies on the addic...

journal_title：Blood

authors： Cramer-Morales K,Nieborowska-Skorska M,Scheibner K,Padget M,Irvine DA,Sliwinski T,Haas K,Lee J,Geng H,Roy D,Slupianek A,Rassool FV,Wasik MA,Childers W,Copland M,Müschen M,Civin CI,Skorski T

更新日期：2013-08-15 00:00:00

abstract：:In this issue of Blood, den Exter et al highlight the importance of subsegmental pulmonary emboli. ...

journal_title：Blood

authors： Raskob GE

更新日期：2013-08-15 00:00:00

abstract：:To ascertain the genetic basis of a paroxysmal nocturnal hemoglobinuria (PNH) case without somatic mutations in PIGA, we performed deep next-generation sequencing on all exons of known genes of the glycosylphosphatidylinositol (GPI) anchor synthesis pathway. We identified a heterozygous germline splice site mutation i...

journal_title：Blood

authors： Krawitz PM,Höchsmann B,Murakami Y,Teubner B,Krüger U,Klopocki E,Neitzel H,Hoellein A,Schneider C,Parkhomchuk D,Hecht J,Robinson PN,Mundlos S,Kinoshita T,Schrezenmeier H

更新日期：2013-08-15 00:00:00

abstract：:Primary effusion lymphoma (PEL) is an aggressive subtype of non-Hodgkin lymphoma characterized by short survival with current therapies, emphasizing the urgent need to develop new therapeutic approaches. Brentuximab vedotin (SGN-35) is an anti-CD30 monoclonal antibody (cAC10) conjugated by a protease-cleavable linker ...

journal_title：Blood

authors： Bhatt S,Ashlock BM,Natkunam Y,Sujoy V,Chapman JR,Ramos JC,Mesri EA,Lossos IS

更新日期：2013-08-15 00:00:00

abstract：:Prophylactic treatment in severe hemophilia is very effective but is limited by cost issues. The implementation of 2 different prophylactic regimens in The Netherlands and Sweden since the 1970s may be considered a natural experiment. We compared the costs and outcomes of Dutch intermediate- and Swedish high-dose prop...

journal_title：Blood

authors： Fischer K,Steen Carlsson K,Petrini P,Holmström M,Ljung R,van den Berg HM,Berntorp E

更新日期：2013-08-15 00:00:00

abstract：:Protein disulfide isomerase (PDI) derived from intravascular cells is required for thrombus formation. However, it remains unclear whether platelet PDI contributes to the process. Using platelet-specific PDI-deficient mice, we demonstrate that PDI-null platelets have defects in aggregation and adenosine triphosphate s...

journal_title：Blood

authors： Kim K,Hahm E,Li J,Holbrook LM,Sasikumar P,Stanley RG,Ushio-Fukai M,Gibbins JM,Cho J

更新日期：2013-08-08 00:00:00

abstract：:The large multimeric glyocoprotein von Willebrand factor (VWF) is a crucial component of both primary and secondary hemostasis. It is stored in secretory granules of vascular endothelial cells, the Weibel-Palade bodies (WPBs), and is released following stimulation by agonists that raise intracellular Ca(2+) or cyclic ...

journal_title：Blood

authors： Brandherm I,Disse J,Zeuschner D,Gerke V

更新日期：2013-08-08 00:00:00

abstract：:Vascular bypass procedures in the central nervous system (CNS) remain technically challenging, hindered by complications and often failing to prevent adverse outcome such as stroke. Thus, there is an unmet clinical need for a safe and effective CNS revascularization. Vascular endothelial growth factors (VEGFs) are pro...

journal_title：Blood

authors： Gaál EI,Tammela T,Anisimov A,Marbacher S,Honkanen P,Zarkada G,Leppänen VM,Tatlisumak T,Hernesniemi J,Niemelä M,Alitalo K

更新日期：2013-08-01 00:00:00

abstract：:Escape from immune detection favors both tumor survival and progression, and new approaches to circumvent this are essential to combat cancers. Nonvirulent, tumor-tropic bacteria, such as Salmonella typhimurium, can unmask a tumor by transforming it into a site of inflammation; however, the nonspecific invasiveness of...

journal_title：Blood

authors： Massa PE,Paniccia A,Monegal A,de Marco A,Rescigno M

更新日期：2013-08-01 00:00:00

abstract：:Development of acute graft-versus-host disease (aGVHD) predisposes to chronic GVHD with autoimmune manifestations. A characteristic of experimental aGVHD is the de novo generation of autoreactive T cells. Central tolerance is dependent on the intrathymic expression of tissue-restricted peripheral self-antigens (TRA), ...

journal_title：Blood

authors： Dertschnig S,Nusspaumer G,Ivanek R,Hauri-Hohl MM,Holländer GA,Krenger W

更新日期：2013-08-01 00:00:00

abstract：:The development of alloantibodies against von Willebrand factor (VWF) represents a rare but serious complication of treatment of von Willebrand disease (VWD), occurring in ~5% to 10% of type 3 VWD patients. Affected patients can present with a range of symptoms, including lack or loss of hemostatic response to infused...

journal_title：Blood

authors： James PD,Lillicrap D,Mannucci PM

更新日期：2013-08-01 00:00:00

abstract：:In this issue of Blood, Doyle et al provide evidence that knockout of the genes encoding the two most abundant eosinophil secondary granule proteins disrupts the normal differentiation of eosinophils from progenitors in the bone marrow, providing a novel strain of mice with a highly specific deficiency in eosinophilop...

journal_title：Blood

authors： Ackerman SJ

更新日期：2013-08-01 00:00:00

abstract：:AALL07P2 evaluated whether substitution of Erwinia asparaginase 25000 IU/m(2) for 6 doses given intramuscularly Monday/Wednesday/Friday (M/W/F) to children and young adults with acute lymphoblastic leukemia and clinical allergy to pegaspargase would provide a 48-hour nadir serum asparaginase activity (NSAA) ≥ 0.10 IU/...

journal_title：Blood

authors： Salzer WL,Asselin B,Supko JG,Devidas M,Kaiser NA,Plourde P,Winick NJ,Reaman GH,Raetz E,Carroll WL,Hunger SP

更新日期：2013-07-25 00:00:00

abstract：:Reprogramming of somatic cells to desired cell types holds great promise in regenerative medicine. However, production of transplantable hematopoietic stem cells (HSCs) in vitro by defined factors has not yet been achieved. Therefore, it is critical to fully understand the molecular mechanisms of HSC development in vi...

journal_title：Blood

authors： Wang L,Liu T,Xu L,Gao Y,Wei Y,Duan C,Chen GQ,Lin S,Patient R,Zhang B,Hong D,Liu F

更新日期：2013-07-18 00:00:00